byFarha, Samar; Sharp, Jacqueline; Asosingh, Kewal; Park, Margaret; Comhair, Suzy A. A.; Tang, W. H. Wilson; Thomas, Jim; Farver, Carol; Hsieh, Fred; Loyd, James E.; Erzurum, Serpil C.
This article is from Pulmonary Circulation, volume 2.AbstractA proliferation of mast cells around the small pulmonary blood vessels and the alveolar septae has been noted in models of pulmonary hypertension, and in plexiform lesions of pulmonary arterial hypertension (PAH) in patients. Here, we hypothesize that total mast cell numbers and activation are increased in PAH and that they contribute to vascular remodeling through cellular and soluble proangiogenic effectors. To test this, blood and... Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401876